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Molecular docking study of binding of green tea catechins to human serum albumin (CROSBI ID 637105)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija

Matić, Sara ; Stepanić, Višnja Molecular docking study of binding of green tea catechins to human serum albumin // 6th Visegrad Symposium on Structural Systems Biology Book Of Abstracts / Długosz, M ; Setny P ; Sułkowska, J et al. (ur.). Varšava, 2016. str. 53-53

Podaci o odgovornosti

Matić, Sara ; Stepanić, Višnja

engleski

Molecular docking study of binding of green tea catechins to human serum albumin

Catechins are the most abundant polyphenols in green tea. Their biological activities beneficial to human health [1] depend on their metabolism and free plasma concentration. In plasma, polyphenols bind to serum albumin, responsible for their transport and storage [2]. In our work, molecular docking has been performed in order to determine the binding specificity and affinity of catechins EGCG, EGC and EC, as well as their metabolites, for binding to site 1 of HSA. Higher affinity has been determined for larger ligands, with more polar or negatively charged groups, such as EGCG and sulfated or glucuronidated metabolites of catechins. The study shows comparable docking results to those of some drugs known to be good ligands of HSA, also indicating their potential competition. [1] Chow, H. H. S. ; Hakim, I. A. Pharmacol. Res. 2011, 64, 105 [2] Zinellu, A. ; Sotgia, S. ; Scanu, B. ; Forteschi, M. ; Giordo, R. ; Cossu, A. ; Posadino, A. M. ; Carru, C. ; Pintus, G. PLoS One 2015, 10, e0134690

catechin ; polyphenol ; serum albumin ; molecular docking

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Podaci o prilogu

53-53.

2016.

objavljeno

Podaci o matičnoj publikaciji

6th Visegrad Symposium on Structural Systems Biology Book Of Abstracts

Długosz, M ; Setny P ; Sułkowska, J ; Trzaskowski, B

Varšava:

Podaci o skupu

6th Visegrad Symposium on Structural Systems

poster

19.06.2016-21.06.2016

Varšava, Poljska

Povezanost rada

Kemija, Temeljne medicinske znanosti, Biologija