engleski

The effects of olanzapine or fluphenazine on peripheral biochemical markers in schizophrenic patients

Abnormal serotonergic and neuroendocrine functions, with altered peripheral biochemical markers (platelet serotonin (5-HT), plasma prolactin (PRL) and cortisol concentrations), are implicated in the pathophysiology of schizophrenia. Aim was to evaluate the effects of olanzapine or fluphenazine on peripheral biochemical markers in schizophrenic patients, and to compare pretreatment values with the values in 22 healthy controls. In a double-blind study 22 schizophrenic patients were treated with olanzapine or fluphenazine (10-20 mg/day) for 5 months, and neuroleptic-induced changes of platelet 5-HT, plasma PRL and cortisol concentrations were determined. Olanzapine decreased significantly total or positive PANSS scores. Platelet 5-HT concentration did not differ between healthy controls and neuroleptic-treated schizophrenic patients. Plasma cortisol levels were significantly higher in schizophrenic patients at baseline than in healthy persons, and in fluphenazine than in olanzapine treated patients after treatment. Plasma PRL were significantly higher after both neuroleptics in schizophrenic patients than in healthy controls, and after fluphenazine treatment when compared to baseline values, and to values in olanzapine treated patients after treatment. Platelet 5-HT concentration, although higher in schizophrenic patients than in healthy subjects, was not affected by olanzapine or fluphenazine treatment. Hypercortisolemia and hyperprolactinemia were observed only after fluphenazine treatment. Treatment with olanzapine, in contrast to fluphenazine, significantly decreased PANSS scores, suggesting that olanzapine has beneficial effects and shows less sideffects in the treatment of schizophrenia.

schizophrenia; biochemical markers; olanzapine; fluphenazine

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