Cytogenetic damage in exfoliated oral buccal cells by dental composites (CROSBI ID 230532)
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Podaci o odgovornosti
Tadin, Antonija ; Galić, Nada ; Marović, Danijela ; Gavic, Lidia ; Klarić, Eva ; Pejda, Slavica ; Ugrin, Klara ; Željezić, Davor
engleski
Cytogenetic damage in exfoliated oral buccal cells by dental composites
Purpose: To evaluate the possible geno/cytotoxic effects of dental composite materials by assessing the frequency of micronuclei formation and other nuclear abnormalities in the exfoliated buccal epithelium. Methods: Swabs were taken from the buccal mucosa among 85 young healthy subjects. All participants had healthy dentition or dentition restored only with composite materials. Genotoxicity and cytotoxicity was assessed by micronucleus assay. Results: The results indicated no significant difference in number of oral mucosa cells with micronuclei in subjects with different numbers of composite restored tooth surfaces (P=0476). Also, the number of restored surfaces had no effect on nuclear alterations closely related to cytotoxicity, such as karyolysis (P=0.572), karyorrehexis (P=0.573) and picnosis (P=0.765).
genotoxic effects ; cytotoxic effects ; dental composite materials ; micronucleus assay ; buccal mucosa cells
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