Templated nucleotide addition and immunoglobulin JH-gene utilization in t(11;14) junctions: Implications for the mechanism of translocation and the origin of mantle cell lymphoma. (CROSBI ID 94764)
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Welzel, Natascha ; Le, Trang ; Marculescu, Rodrig ; Mitterbauer, Gerlinde ; Chott, Andreas ; Pott, Christine ; Kneba, Michael ; Du, Ming-Qing ; Kušec, Rajko ; Drach, Johanes ; Raderer, Markus ; Mannhalter, Christine ; Lechner, Klaus ; Nadel, Bertrand ; Jaeger, Ulrich
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Templated nucleotide addition and immunoglobulin JH-gene utilization in t(11;14) junctions: Implications for the mechanism of translocation and the origin of mantle cell lymphoma.
The t(11;14) (q13;q32) between the BCL-1 and immunoglobulin heavy chain gene (Ig-H) loci in mantle cell lymphomy (MCL) are believed to be mediated by the mechanism of V(D)J recombination similar to the t(14;18) in follicular lymphoma. We have recently shown that the t(14;18) event creates staggered double-strand breaks in the BC-2 locus, and that the t(14;18) junctions contain templated nucleotide insertions (T-nucleotides)...
template nucleotide addition; JH-gene utilization; mantle cell lymphoma
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Povezanost rada
Kliničke medicinske znanosti