engleski

Use of an Octapeptide-Guanidiniocarbonylpyrrole Conjugate for the Formation of a Supramolecular beta-Helix that Self-Assembles into pH-Responsive Fibers

Peptides which adopt β-helix structures are predominantly found in transmembrane protein domains or in the lipid bilayer of vesicles. Constructing a β-helix structure in pure water has been considered difficult without the addition of membrane mimics. Herein we report such an example ; peptide 1 which self-assembles into a supramolecular β-helix in pure water based on charge interactions between the individual peptides. Peptide 1 further showed intriguing transitions from small particles to helical fibers in a time dependent process. The fibers can be switched to vesicles by changing the pH value.

self-assembly ; molecular recognition ; peptide structure ; ion pair formation ; peptide fibres

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