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Secondary expansion of the transient subplate zone in the developing cerebrum of human and nonhuman primates (CROSBI ID 231337)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Duque, Alvaro ; Krsnik, Željka ; Kostović, Ivica ; Rakić, Paško Secondary expansion of the transient subplate zone in the developing cerebrum of human and nonhuman primates // Proceedings of the National Academy of Sciences of the United States of America, 113 (2016), 35; 9892-9897. doi: 10.1073/pnas.1610078113

Podaci o odgovornosti

Duque, Alvaro ; Krsnik, Željka ; Kostović, Ivica ; Rakić, Paško

engleski

Secondary expansion of the transient subplate zone in the developing cerebrum of human and nonhuman primates

he subplate (SP) was the last cellular compartment added to the Boulder Committee’s list of transient embryonic zones [Bystron I, Blakemore C, Rakic P (2008) Nature Rev Neurosci 9(2):110–122]. It is highly developed in human and nonhuman primates, but its origin, mode, and dynamics of development, resolution, and eventual extinction are not well understood because human postmortem tissue offers only static descriptive data, and mice cannot serve as an adequate experimental model for the distinct regional differences in primates. Here, we take advantage of the large and slowly developing SP in macaque monkey to examine the origin, settling pattern, and subsequent dispersion of the SP neurons in primates. Monkey embryos exposed to the radioactive DNA replication marker tritiated thymidine ([3H]dT, or TdR) at early embryonic ages were killed at different intervals postinjection to follow postmitotic cells' positional changes. As expected in primates, most SP neurons generated in the ventricular zone initially migrate radially, together with prospective layer 6 neurons. Surprisingly, mostly during midgestation, SP cells become secondarily displaced and widespread into the expanding SP zone, which becomes particularly wide subjacent to the association cortical areas and underneath the summit of its folia. We found that invasion of monoamine, basal forebrain, thalamocortical, and corticocortical axons is mainly responsible for this region-dependent passive dispersion of the SP cells. Histologic and immunohistochemical comparison with the human SP at corresponding fetal ages indicates that the same developmental events occur in both primate species.

cerebral cortex ; brain evolution ; transient lamination ; neuronal migration ; neural stem cells

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o izdanju

113 (35)

2016.

9892-9897

objavljeno

0027-8424

10.1073/pnas.1610078113

Povezanost rada

Temeljne medicinske znanosti

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