engleski

IDIOSYNCRATIC REACTIONS: LABORATORY ANSWERS TO CLINICAL QUESTIONS

Idiosyncratic drug reactions (IDR) are rare, dose independent adverse drug reactions. Although non-predictable they are not idiopathic and their causes can be rationalized. As IDRs appear rarely (with a frequency of less than 0.1%) they are encountered when a drug comes to the market and is exposed to larger population. Drugs susceptible to IDRs usually undergo extensive metabolism, consequently most common IDR is hepatotoxicity caused by reactive metabolites. In this presentation laboratory approaches in search of reactive metabolites will be discussed. Some of the topics covered: why did structurally similar pioglitazone and rosiglitazone outsurvive troglitazone, why is paracetamol still the leading cause of acute liver failure, is glucuronidation detoxication reaction, can parent drugs be responsible for enzyme inactivation?

IDR; reactive metabolites; drug metabolism

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