Patients complience correlates to pharmacogenomics of drugs used in the treatment of early stage breast cancer (CROSBI ID 639133)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa
Podaci o odgovornosti
Bojanić, Kristina ; Kizivat, Tomislav ; Kuna, Lucija ; Wagner, Jasenka ; Smolić, Robert ; Bilić-Čurčić, Ines ; Kralik, Kristina ; Smolić, Martina, Tucak, Antun ; Včev, Aleksandar
engleski
Patients complience correlates to pharmacogenomics of drugs used in the treatment of early stage breast cancer
Anastrozole is a selective competitive aromatase inhibitor (AI) widely used as adjuvant treatment for early stage breast cancer. Highly efficient estrogen depletion by AI benefits breast cancer (BC) patients by extending recurrence-free survival. However, AIs put patients at high risk of osteoporosis due to the central role of estrogen in maintaining normal bone metabolism. Although awareness of osteoporosis by health care professionals has increased in recent years, it remains underdiagnosed and undertreated. Findings of this study should raise awarness of the importance of BMD screening among BC patients treated with anastrazole and to tailor treatment and prevention strategies for Al users as a high - risk population for bone morbidity. The intensity of adverse effects plays an essential part in maintaining patient complience to anastrazole therapy. Functional genetic polymorphisms of enzymes involved in anastrazole metabolism could be correlated to altered aromatase activity, disease prognosis and severity of aromatase inhibitor adverse effects, however large genotyping studies are obligatory.
pharmacogenetics ; breast cancer ; aromatase inhibitor ; adverse drug reactions ; osteoporosis ; hepatotoxicty
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
Podaci o prilogu
xx-xx.
2016.
nije evidentirano
objavljeno
Podaci o matičnoj publikaciji
IUAES - World anthropologies and privatization of knwoledge: engaing anthropology in public
Podaci o skupu
IUAES - World anthropologies and privatization of knwoledge: engaing anthropology in public
poster
04.05.2016-09.05.2016
Dubrovnik, Hrvatska