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Synthesis and characterization of two novel copper(II) complexes with L-serine and 1, 10- phenantroline

Amino acid complexes with transition metals have been of great interest over the last decades for their use as model systems for studying interactions in biological processes (Beck, 2009 ; Santana et al., 2005). Moreover, amino acids and planar heterocyclic bases combined into ternary metal complexes show variable biological activities, such as DNA binding and cleavage, antibacterial and antiproliferative activities (Liu et al., 2013). Two complexes of copper(II) with L- serine and 1, 10-phenantroline – [Cu(Ser) (H2O) (phen)]2SO4 · 6H2O (A), and [Cu(Ser)(CH3OH) (phen)]2SO4 · 2CH3OH (B) (Ser = L-serine, phen = 1, 10- phenantroline) – were synthesized and structurally characterized (Fig. 1). Complex A was prepared by solvothermal and mechanochemical methods. The complex crystallizes in the monoclinic crystal system, space group P 21, a= 6.7638(6) Å, b= 21.2866(18) Å, c= 13.3906(13) Å, β= 101.891(9)°, at 150 K. Complex B was synthesized solvothermally. This complex also crystallizes in monoclinic crystal system but in the space group I 2, a= 13.2086(9) Å, b= 7.7582(6) Å, c= 19.0599(14) Å, β= 98.068(7)°, at room temperature. In this structure, sulfate ion is disordered over two positions as it lays on the two–fold axis. Complex cations in both structures have a distorted square pyramidal geometry of the copper atom being coordinated by one phenatroline ligand, one serine and a methanol (B) or a water (A) molecule. More detailed properties of crystal structures and synthesis will be presented in the lecture.

copper(II) complex ; crystal structure ; 1 ; 10-phenantroline ; L-serine

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