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Structure and Stability of FlgD from the Pathogenic 26695 Strain of Helicobacter pylori (CROSBI ID 232065)

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Kekez, Ivana ; Cendron, Laura ; Stojanović, Mario ; Zanotti, Giuseppe ; Matković-Čalogović, Dubravka Structure and Stability of FlgD from the Pathogenic 26695 Strain of Helicobacter pylori // Croatica chemica acta, 89 (2016), 2; 229-235. doi: 10.5562/cca2942

Podaci o odgovornosti

Kekez, Ivana ; Cendron, Laura ; Stojanović, Mario ; Zanotti, Giuseppe ; Matković-Čalogović, Dubravka

engleski

Structure and Stability of FlgD from the Pathogenic 26695 Strain of Helicobacter pylori

Flagellin component D (FlgD) is a hook capping protein involved in the proper structural assembly of bacterial flagella but is not present in the mature flagella. We report here the crystal structure of the truncated form of FlgD from the strain 26695 of Helicobacter pylori (HpFlgD_26695) in the P2 space group at 2.8 Å resolution, along with data on protein stability. The structure includes only the central globular part of the protein composed of conserved Fn-III and tudor domains, while the N- and C-terminal regions are absent. This structure, together with the tetragonal crystal structure of HpFlgD_26695 and the monoclinic crystal structure of HpFlgD_G27 reported previously, revealed a different mutual orientation of the two domains in the HpFlgD structures in respect to FlgD from Xanthomonas campestris and Pseudomonas aeruginosa. In addition, investigation of protein stability in solution showed higher protein stability then in other bacterial orthologues reported so far.

Helicobacter pylori ; strain 26695 ; FlgD ; stability ; monoclinic crystal structure

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Podaci o izdanju

89 (2)

2016.

229-235

objavljeno

0011-1643

1334-417X

10.5562/cca2942

Povezanost rada

Kemija

Poveznice