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Biological activity of isolated compounds from Centaurea ragusina L. (CROSBI ID 640224)

Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | međunarodna recenzija

Vujčić, Valerija ; Radić Brkanac, Sandra ; Radić Stojković, Marijana ; Žilić, Irena ; Tolić, Sonja ; Krivohlavek, Adela ; Ivanković, Siniša ; Ivanković, Dušica ; Stojković, Ranko ; Hrenović, Jasna et al. Biological activity of isolated compounds from Centaurea ragusina L. // Arhiv za higijenu rada i toksikologiju / Durgo, Ksenija (ur.). 2016. str. 42-42

Podaci o odgovornosti

Vujčić, Valerija ; Radić Brkanac, Sandra ; Radić Stojković, Marijana ; Žilić, Irena ; Tolić, Sonja ; Krivohlavek, Adela ; Ivanković, Siniša ; Ivanković, Dušica ; Stojković, Ranko ; Hrenović, Jasna ; Ruščić, Mirko ; Grienke, Ulrike ; Rollinger, Judith Maria

engleski

Biological activity of isolated compounds from Centaurea ragusina L.

Antioxidant, antibacterial, and cytotoxic activity of three flavonoids (chrysin, oroxylin A, and hispidulin) and sesquiterpene lactones (hemistepsin A, deacylcynaropicrin and (3aR, 4S, 6aR, 8S, 9aR, 9bR)-[Dodecahydro-8- dihydroxy-3, 6, 9- tris(methylene)-2oxo-2(3H)- azuleno[4, 5-b]furanyl]-3-methyl-butanoate) isolated from ethanolic extract of the Croatian endemic plant species Centaurea ragusina L. were studied. The interactions of isolated compounds with double stranded polynucleotides ctDNA and poly A – poly U (possible biological targets) were studied with circular dichroism spectroscopy (CD spectroscopy) at pH=5.0 and pH=7.0 to provide a better understanding of the biological activity of the tested compounds. Flavonoid hispidulin showed moderate antioxidant activity measured by the ABTS method while other isolated compounds from ethanolic extract showed weak antioxidant activity. Two sesquiterpene lactones (3aR, 4S, 6aR, 8S, 9aR, 9bR)-[Dodecahydro-8-dihydroxy-3, 6, 9-tris(methylene)-2oxo-2(3H)-azuleno[4, 5- b]furanyl]-3- methyl-butanoate) and hemistepsin A showed significant antibacterial activity against Staphylococcus aureus ATCC25923 (MIC 31.3 g mL-1). All tested compounds showed weak antibacterial activity against Acinetobacter baumannii DURN. Among the isolated compounds, only (3aR, 4S, 6aR, 8S, 9aR, 9bR)-[Dodecahydro- 8-dihydroxy-3, 6, 9-tris(methylene)-2oxo- 2(3H)-azuleno[4, 5-b]furanyl]-3-methyl- butanoate) exerted selective and prominent tumour cell-growth inhibitory activity towards SCCVII cell line (IC50 = 2.55μM). Simultaneously, (3aR, 4S, 6aR, 8S, 9aR, 9bR)- [Dodecahydro-8-dihydroxy- 3, 6, 9- tris(methylene)-2oxo-2(3H)-azuleno[4, 5- b]furanyl]-3-methyl-butanoate) showed a weak interaction with DNA indicating that some other target/mechanism is responsible for its prominent cytotoxic activity towards SCCVII cell line.

biological activity ; flavonoid ; sesquiterpene lactones interactions with polynucleotides

Naziv projekta: Biološka aktivnost fitokemikalija biljne vrste Centaurea ragusina L.(BioFitoCen) Šifra projekta: HR.3.2.01-0290 Projekt sufinancira Europska unija: iz Europskog socijalnog fonda u sklopu programa Razvoj ljudskih potencijala 2007. – 2013.

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Podaci o prilogu

42-42.

2016.

nije evidentirano

objavljeno

Podaci o matičnoj publikaciji

Arhiv za higijenu rada i toksikologiju

Durgo, Ksenija

Zagreb: Institut za medicinska istraživanja i medicinu rada

0004-1254

1848-6312

Podaci o skupu

The 5th Croatian Congress of Toxicology with International Participation, CROTOX 2016.

poster

09.10.2016-12.10.2016

Poreč, Hrvatska

Povezanost rada

Biologija

Poveznice
Indeksiranost