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Hedgehog Signaling Pathway as Genetic and Epigenetic Target in Ovarian Tumors

Hedgehog signaling pathway is a developmental pathway mostly inactive in adult tissues, with the exception of stem cells. It is often found upregulated in various tumors, and associated with cancer stem cell maintenance. Mutations in pathway components lead to a series of developmental malformations and syndromes. Aberrant activation of the pathway can be caused by mutations, non-canonical transcriptional regulation, or epigenetic changes. This makes this pathway an interesting target in cancer therapy, especially when combined with therapies targeting other signaling pathways. Combination therapy can be used to bypass resistance or to target cancer stem cells in a more efficient way. This review focuses on different aspects of Hedgehog activation in tumors, with special emphasis on ovarian tumors and their treatment.

Hedgehog signaling ; ovarian tumors ; cyclopamine ; miRNA ; methylation ; mutation ; therapy

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