engleski

Traumatic brain injury: new insights into time and region specific secondary damage processes as potential therapeutic targets

Traumatic brain injury (TBI) is a major health problem and one of the main causes of mortality and morbidity in the young population. TBI pathophysiology develops as the result of the primary injury of the brain tissue and cerebral vasculature caused by the direct mechanical force. The following secondary events, such as the excitotoxicity, ischemia, free radicals' generation and inflammation, lead to cell injury and death. These processes develop within days, weeks and months after the injury and they are potentially susceptible to therapeutic intervention. Most of the TBI research, both preclinical and clinical, has been focused on the changes in the cerebral cortex and the hippocampus but various studies also indicate that TBI causes extensive cellular and axonal changes which extend to brain regions far beyond the area of the primary injury. The damage of these remote brain structures might be of importance for the development of numerous post-injury neurological sequelae. Here, a summary of the current knowledge regarding temporal and regional pattern of the neuropathological alterations which develop after the brain trauma will be presented.

brain regions ; cell death ; inflammation ; rat ; traumatic brain injury ;

nije evidentirano