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Rosuvastatin reduces kidney malondialdehyde concentrations in rats (CROSBI ID 640847)

Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | domaća recenzija

Rašić, Dubravka ; Vukšić, Antonija ; Peraica, Maja ; Lovrić, Jasna ; Bradamante, Vlasta Rosuvastatin reduces kidney malondialdehyde concentrations in rats // Arhiv za higijenu rada i toksikologiju / Durgo, Ksenija (ur.). 2016. str. 37-37

Podaci o odgovornosti

Rašić, Dubravka ; Vukšić, Antonija ; Peraica, Maja ; Lovrić, Jasna ; Bradamante, Vlasta

engleski

Rosuvastatin reduces kidney malondialdehyde concentrations in rats

Statins are drugs widely used to treat hypercholesterolemia and reduce the risk of cardiovascular morbidity and mortality in patients with coronary heart disease. The mechanism of their action may be the inhibition of oxidant formation and blocking the effects of reactive oxygen species (ROS). As reported in recent studies, rosuvastatin has a beneficial effect on the plasma lipid profile and can reduce serum cholesterol and ROS formation in diabetic patients. The aim of this work was to determine the influence of rosuvastatin on the prooxidant- antioxidant balance in rat kidneys. This study was performed on male normolipidemic Wistar rats (N=36) divided into two control (treated with saline 5 mg kg-1 per day) and two experimental rosuvastatin-treated (5 and 10 mg kg-1 per day) groups. Animals were treated orally for 21 days. Malondialdehyde (MDA) – parameter of lipid peroxidation was measured in the kidney tissue homogenate of control and treated animals using the method by Drury et al. (1997). Data were analysed using t-test. Results are expressed as Mean±STD. MDA concentration was significantly lower in both experimental groups compared to controls: 0.41±0.05 vs. 0.62±0.08 µmol g-1 tissue (5 mg kg-1 per day vs. control ; p<0.001) and 0.58±0.05 vs. 0.68±0.09 µmol g-1 tissue (10 mg kg- 1 per day vs. control ; p<0.05). Our results have shown that rosuvastatin possesses significant antioxidative effectiveness that is not dose- dependent. This antioxidative action extends beyond the lipid-lowering effects of statins.

Lipid peroxidation ; oxidative stress ; rats ; statins

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Podaci o prilogu

37-37.

2016.

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objavljeno

Podaci o matičnoj publikaciji

Arhiv za higijenu rada i toksikologiju

Durgo, Ksenija

Zagreb: Institut za medicinska istraživanja i medicinu rada

0004-1254

1848-6312

Podaci o skupu

5th Croatian Congress of Toxicology with International Participation

poster

09.10.2016-12.10.2016

Poreč, Hrvatska

Povezanost rada

Temeljne medicinske znanosti

Poveznice
Indeksiranost