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Design of novel hybrid compounds of vitamin C and 1, 2, 3-triazole with anticancer properties – impact of physicochemical profile on biological activity

Vitamin C has been known as a reducing agent with a number of biological functions (Du et al., Biochim Biophys Acta 2012). On another side, compounds with a 1, 2, 3-triazole fragment have shown antiproliferative activities against a variety of cancer cell lines (Kraljević et al., Eur J Med Chem 2016). Design of a library of novel hybrid compounds of vitamin C and 1, 2, 3-triazole with various physicochemical characteristics (such as lipophilicity and solubility) and antioxidant capacity, through interdisciplinary approach will be outlined. The molecular properties have been modulated through introduction of various substituents at the C-4 atom of 1, 2, 3-triazole and their impact on biological activities has been estimated by using in silico modelling (Cruciani et al., J Mol Struct Theochem 2000), which will be presented.

vitamin C; 1; 2; 3-traizole; hybrids; antiproliferative; physico-chemical properties

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