engleski

Reactions with N-(1-benzotriazolylcarbonyl)-amino acids. 4. The use of N-(1-benzotriazolylcarbonyl)-amino acid derivates in peptide synthesis

The use of the 1-benzotriazolylcarbonyl-(Btc)-group as an N-protecting and N-activating group in the synthesis of peptides was investigated. Removal of the Btc group from N-Btc-amino acids, their esters and amides under acidic conditions is possible, but has no advantages over removal of benzyloxycarbonyl-(Z)-group. N-Btc-amino acid esters react with Z-amino acids or Z-dipeptides yielding Z-dipeptide and Z-tripeptide esters, respectively. This process is accompanied with separation of benzotriazole and CO2. Advantages and disadvantages of this method of peptide bond formation are discussed.

benzotriazole ; peptide synthesis

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