engleski

De novo assembly using long error-prone reads

Assembling genomes from long error-prone reads without error correction seems like a promising method. The thesis shows that layout methods used for assembling genomes from short reads can be utilized for assembling from long error- prone reads, if coupled with new methods for eliminating the noise from a dataset. Methods are validated with two datasets of Escherichia coli (PacBio and Oxford Nanopore Technologies). Results are compared with results of the miniasm assembler.

De novo assembly; PacBio; Oxford Nanopore Technologies; layout

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