engleski

Vitamin D deficiency in peripubertal stage. What can we do?

Aim: In the study which investigated the association of selected genetic polymorphisms and bone mineral density (BMD) in boys reaching puberty we observed serum level of vitamin D and influence of nutrition and behaviour paqtterns on ultrasounds bone mineral parameters too. After 5 years we did same survey on nutrition and behavior paterns, serums level of vitamin D and calcium and ultrasounds parameters. Matherial: We started 2009. and analysed all ultrasound parameters of calcanues with antrophometrics, biochemics and hormonal state at 78 boys between 11-13 years residing in Slavonski Brod, Croatia. We did same measuring 2013. and compared all parameters. Quantitative ultrasound measurements were undertaken with Sahara device (Hologic). We estimated dietary habits and other possible behavioural patterns associated with BMD: ( TV watching, use of computer, sun exposure /summer/winter/ hours per week, fizzy drinks/ dcl per day). The data were presented with T -test. A multiple linear regression model was used in the final analysis step. SPSS Inc, Chicago, IL was used, significance at P<0.05. Results: Hormonal and biochemical parameters were normal and they don't affect on BMD. Significant low levels of serum concentration of vitamin 25 (0H) D3 (28.6 nmol / l (2009. ) and 27, 6 nmol / l . 2013.was found in both measuring. The same did not show any statistical association with the ultrasound parameters. A positive correlation between daily calcium intake was confirmed. Children who took 850 mg of calcium per day had better parameters of BMD. We found that all behavior patterns hadn't significantly changed during this period. 34% boys take 5 dcl of fizzed drinks daily, 48% ingest daily 600 mg of calcium and 63% sits 4h during computer use. Their physical activity is extremely low ( 10% go out about 30-60 min 2x per week) ; as a sun exposition, too (about 1 hour during summer at 23% examinees ; on winter about 15 min at 15%). Discusion: An alarming fact is that the serum concentration of vitamin D3 that was found was significantly below normal in both measuring. Blood analysis was done in mid June after a long sunny period. 63% of the children spend most of his free time in front of TV or computer. Most children consumed foods low in vitamin D and they are generally less active. Conclusion: Low serum vitamin D had no effect on bone metabolism? The question is whether the observed children achieved some extraskeletal effect of vitamin D due to this finding. We think it is necessary to consider the status of vitamin D3 in the pediatric population. It's well-known the association of vitamin D levels with the development allergic or other autoimmune diseases. The results point out the possible need supplementation with vitamin D during puberty as well as education on style of life and nutrition.

Vitamin D ; puberty

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