engleski

Detection of radiation hypersensitivity to occupational exposure to ionizing radiation by stable and unstable chromosome aberrations

A subject occupationally exposed to 192Iridium during a period of 15 months who had shown a significant increase in chromosome aberrations with the annual dose below 50 mSv was analysed by in situ hybridisation in order to evaluate frequency of stable translocations and related health risk. Lymphocytes from the subject were scored using chromosome aberration assay and fluorescent in situ hybridization. Blood samples were taken on four occasions over a period of 2 years. The frequency of translocations measured by fluorescent in situ hybridization (0, 026 per cell) was significantly elevated over published control (0, 003 translocations per cell). Fluorescent in situ hybridization confirmed that chromosome damage was not the consequence of accidental overexposure it is concluded that the subject expresses radiation hypersensitivity.

ionizing radiation; hypersensitivity to radiation; FISH

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