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In vivo micronucleus assay-control values for children of 0.7 years age (CROSBI ID 484163)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija

Fučić, Aleksandra ; Lasan, Ružica ; Hitrec, Vlasta In vivo micronucleus assay-control values for children of 0.7 years age // Environmental and Molecular Mutagensis / Heflich r.H. (ur.). Hoboken (NJ): Wiley-Liss, 2001. str. 33-x

Podaci o odgovornosti

Fučić, Aleksandra ; Lasan, Ružica ; Hitrec, Vlasta

engleski

In vivo micronucleus assay-control values for children of 0.7 years age

The development of new biomonitoring methods for evaluation of health risk due to environmental contamination or parental exposire redefines the child's position. The child is no longer a small human being but a unique entity with specific response to environment especially in first few years of life. Small blood sample and the quickness of the procedure, as it does not rquire cell culture, makes in vivo micronucleus assay elegant method for biomonitoring of children. The in vivo micronucleus assay is preferentially applied in genotoxicological experiments with rodents (Hayashi et al 1997). The results of biomonitoring of human population using this method are limited. We analysed 30 chiildren aged from 0-7 years. the results show that the average frequency of micronuclei in peripheral blood is 0,21%. There was no significant differences in micronuclei frequency between girls and boys. These agrees with published data for adult population (Xue et al., 1992). Small interindividual differences, low cost of method and quick results mark this method as suitable for biomonitoring of genome damage in children after exposure to clastogens and aneugens via environmental pollution. Small blood samples amkes the method applicable even in early postnatal period. Further research should give data on sensitivity of method and stability of this biomarker.

in vivo micronucleus assay; children

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Podaci o prilogu

33-x.

2001.

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objavljeno

Podaci o matičnoj publikaciji

Environmental and Molecular Mutagensis

Heflich r.H.

Hoboken (NJ): Wiley-Liss

Podaci o skupu

Conference of Environmental Mutagen Society: A Science Odyssey

poster

16.03.2001-21.03.2001

San Diego (CA), Sjedinjene Američke Države

Povezanost rada

Temeljne medicinske znanosti