engleski

Comparison of the eliminationof unstable chromosome aberrations and stable chromosome aberrations in population involved in industrial radiography

The rate of elimination, persistance and the accumulation of genetic damage are of great importance in epidemiologic studies of occupationally exposed population in industry as the conditions of induction of such damages are different from those described in medicine or nuclear plants. We investigated twenty subjects occupationally exposed to 192Ir or 137 Cs by chromosome aberrations assay and eight of them by fluorescent in situ hybridization (FISH)over a period of two years. Physical dosimetry showed that the annual doses kept below 50 mSv. Repeated analysis showed that the earlier found bicentric and ring chromosomes were eliminated during the period of one year, which confirms in the same time that detected aberrations were not constitutive. Our results show that frequency of translocations (0,022 translocations/cell on average) deviates from control values and that it does not correlated with years of employment.There is no possibility to make extrapolations or predict accumulation of trasnlocations by measuirng unstable aberrations as detected genome damage shows unequal distribution as a consequence of differences in individual activity at work place. In conclusion is that the evaluation relying on chromosome aberration assay is likely to underestimate the actual health risk of long term exposure to low doses of ionizing radiation in industrial radiography.

FISH; dicentric; translocation

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