Molecular dynamic study of the antimicrobial peptide maculatin 1.1 stabilization of the preformed pore (CROSBI ID 643364)
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Podaci o odgovornosti
Sonavane, Yogesh ; Zoranić, Larisa
engleski
Molecular dynamic study of the antimicrobial peptide maculatin 1.1 stabilization of the preformed pore
Antimicrobial peptides (AMP) are the first line of defense against pathogens in all organisms [1]. The mechanism by which these peptides break structure can be by tearing up the lipid bilayer or by inducing the pore formation in the membrane [2, 3]. The key element of the AMPs activity is that they are highly selective, being toxic against a broad range of microorganisms, and not to the host cells. The part of the extensive study which exploits the high level of detail obtainable via molecular dynamics simulations of AMP maculatin in membrane environment, is presented in the following study. We analyzed stabilization of the preformed pore in the neutral phosphatidylcholine (PC) membranes with the different chain length. Our aim is to understand possible relation between lipid composition and some of the proposed mechanisms of action of the antimicrobial peptides.
antimicrobial peptides; molecular dynamics; maculatin; membranes
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Podaci o prilogu
2016.
objavljeno
Podaci o matičnoj publikaciji
International workshop on Biomembranes: The consequences of complexity.
Podaci o skupu
International workshop on Biomembranes: The consequences of complexity
poster
16.09.2016-19.09.2016
Espoo, Finska