Nalazite se na CroRIS probnoj okolini. Ovdje evidentirani podaci neće biti pohranjeni u Informacijskom sustavu znanosti RH. Ako je ovo greška, CroRIS produkcijskoj okolini moguće je pristupi putem poveznice www.croris.hr
izvor podataka: crosbi

Opiorphin in burning mouth syndrome patients: a case-control study (CROSBI ID 234419)

Prilog u časopisu | izvorni znanstveni rad

Salarić, Ivan ; Sabalić, Maja ; Alajbeg, Ivan Opiorphin in burning mouth syndrome patients: a case-control study // Clinical oral investigations, 21 (2017), 7; 2363-2370. doi: 10.1007/s00784-016-2031-9

Podaci o odgovornosti

Salarić, Ivan ; Sabalić, Maja ; Alajbeg, Ivan

engleski

Opiorphin in burning mouth syndrome patients: a case-control study

Objectives Opiorphin is a pentapeptide isolated from human saliva that suppresses pain from chemically induced inflammation and acute physical pain. Burning mouth syndrome (BMS) is a chronic condition of a burning sensation in the mouth, where no underlying dental or medical cause can be identified. We aimed to measure the level of opiorphin in whole unstimulated (UWS) and stimulated (SWS) saliva of patients with BMS. Materials and methods Originally developed and validated LC-MS/MS method was used for opiorphin quantification. Samples were obtained from 29 BMS patients and 29 age- and sex-matched controls. Results The average concentration of opiorphin in UWS and SWS in the BMS group was 8.13 ± 6.45 and 5.82 ± 3.59 ng/ml, respectively. Opiorphin in BMS patients’ UWS was significantly higher, compared to the control group (t = 2.5898 ; p = 0.0122). SWS opiorphin levels were higher, but not significantly, in BMS patients than in controls. Conclusions Our results indicate that higher quantities of salivary opiorphin in BMS may be a consequence of chronic pain, but we cannot exclude that they occur as a result of emotional and behavioral imbalances possibly associated with BMS. To our knowledge, this is the first original article measuring opiorphin in a pain disorder. Clinical relevance Opiorphin may be a measurable biomarker for chronic pain, which could help in objectifying otherwise exclusively a subjective experience. Increased opiorphin could serve as a universal objective indicator of painful conditions. Since opiorphin may also reflect emotional and socio- relational imbalances occurring with BMS, it could as well represent a biomarker for BMS. Knowledge on opiorphin’s involvement in pain pathways could contribute to developing new clinical diagnostic methods for BMS.

Opiorphin ; Burning mouth syndrome ; Saliva ; Chromatography ; Liquid ; Spectrometry ; Mass

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o izdanju

21 (7)

2017.

2363-2370

objavljeno

1432-6981

1436-3771

10.1007/s00784-016-2031-9

Povezanost rada

Dentalna medicina, Kliničke medicinske znanosti, Temeljne medicinske znanosti

Poveznice
Indeksiranost