engleski

Plasma markers of inflammation and hemostatic and endothelial activity in naturally overweight and obese dogs

Overweight and obesity are one of the most prevalent health problems in the canine population. While haemostatic parameters and markers of endothelial function have been evaluated in numerous disease conditions in humans and different animals, there are no studies of these markers in canine weight excess. This study was designed to evaluate the effect of naturally gained overweight and obesity in inflammatory, hemostatic, fibrinolytic and endothelial biomarkers of dogs. A total of 37 overweight and obese dogs were compared with 27 normal weight dogs. Overweight and obese dogs had significantly elevated IL-6 and hsCRP. Number of platelets, activity od factor X and factor VII were significantly higher, while aPTT and suPAR significantly decreased. Statistical analysis of HMGB-1, sICAM-1 and PAI-1 concentrations did not show significant differences between the total overweight and obese group and the normal weight group of dogs. Weight excess in dogs reflect a chronic low degree of inflammation, shifts the hemostatic balance and features a hypercoagulable state, where primary and secondary hemostasis are both affected. Overweight and obesity are not associated with impairment of endothelial function in dogs. The role of suPAR in dogs as an possible indicator of fibrinolytic disturbances is not clear and requires further research.

Canine, IL-6, HsCRP, Clotting factors, Platelets

nije evidentirano