II index is not an accurate indicator of icteria in conjugated hyperbilirubinemia (CROSBI ID 237422)
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Nikolac Gabaj, Nora ; Miler, Marijana ; Mihić, Roman
engleski
II index is not an accurate indicator of icteria in conjugated hyperbilirubinemia
Serum indices have become a standard in assessing degree of endogenous interferences in serum and plasma samples. The aim of this study was to evaluate accuracy of I index in comparison with total bilirubin concentration in icteric samples with ranging amount of conjugated bilirubin. This study retrospectively analyzed data from laboratory information system. Total, conjugated bilirubin and I index are measured on Abbott Architect c8000 (N=900). Agreement between total bilirubin and I index in subgroups according to proportion of direct bilirubin (< 50% and ≥50%) was investigated using Bland-Altman analysis. In samples where percentage of direct bilirubin accounts for< 50% of total bilirubin there was no statistically significant constant difference, while small proportional difference was observed (2.5%) between total bilirubin and I index. In samples where percentage of direct bilirubin accounts for ≥50% of total bilirubin, significant constant (26.6) and proportional difference (22.2%) were observed between total bilirubin and I index. I index is not accurate indicator of icteria if> 50% of bilirubin is conjugated. Manufacturers should declare icteria interference with both, bilirubin concentration and value of I index.
Preanalytical phase ; Laboratory error ; Serum indices ; Interferences ; Icteria
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
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Povezanost rada
Kliničke medicinske znanosti, Farmacija