engleski

Tripeptide hydrogelator (ffa) as a minimalist model of aggregation of a beta proteins

Synthesis, characterization and self-assembly of small peptidic gelators based on amyloid β- protein. Morphology of prepared gels was investigated by Transmission Electron Microscopy (TEM). Organisation in gel assemblies at the molecular and the supramolecular level determined by using spectroscopic methods (NMR, FTIR, CD) pointed towards the β-sheet type of hydrogen bonding self-association of tripeptides in gel aggregates. Binding studies of tripeptide 6 with amyloid dyes, Congo Red and Thioflavin T (ThT) were carried out using fluorescence spectroscopy and confocal microscopy.

tripeptides, gels, Aβ-protein, β-sheet, amyloid dyes, biomaterial,

Predavanje se održalo 2.-3.2.2017.