engleski

Oxycodone in the treatment of chronic musculoskeletal pain - preliminary single- centre experience

In this prospective, open, single-center study of one rheumatology center we enrolled consecutive patients with musculoskeletal pain in variety of musculoskeletal diseases (osteoarthritis, pain in the lower part of the back, spondylarthritis) which despite previous analgesic therapy (with NSAIDs, weak opioids or a fixed combination of paracetamol and weak opioid) suffered from moderate to severe pain. Patients were switched to therapy oxycodone CR and followed for 14 days. The starting dose of oxycodone CR was10 mg, later the dose was adapted according to need. The primary endpoint was to assess the effectiveness of oxycodone CR on pain intensity and secondary goal was to assess the efficiency on the general health of the patient (both on horizontal visual analogue scale, VAS 0 = best- 10 = worst). Fifteen patients (12 women, 3 men), with mean age 61 ± 12 years with the diagnosis of osteoarthritis, pain in the lower part of the back or inflammatory arthritis were included in the study. The duration of pain was 41 ± 12 months. The average intensity of pain before oxycodone CR treatment was 7.87 ± 2.28 (range 7-10), and at the end of the study 5.92 ± 2.43 (range 4- 9). General health was rated 7.27 ± 2.14 (range 3-10) before the start and 6.00 ± 1.53 (range 3-9) at the end of the study. Preliminary results show that in patients with chronic nonmalignant pain which is not well controlled by simple analgesics, NSAIDs and weak opioids, treatment with oxycodone CR contributed to a significant reduction in the level of pain and improved the general health of the patient.

Pain, chronic, treatment, musculoskeletal, oxycodone

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