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Antioxidative activity and metal and pH sensing properties of heteroaromatic benzamides

Within this work, we present the synthesis, spectroscopic characterization and antioxidative activity of novel methoxy and/or hydroxy derivatives of amino substituted benzamides. For the synthesis of novel targeted compounds, classical organic synthesis reactions were used. [1] Amino substituted derivatives were prepared by reduction of nitro analogues while hydroxy substituted benzamide derivatives obtained by the removal of methoxy protecting groups with BBr3. Structures of newly prepared compounds were confirmed by means of 1H and 13C NMR, UV/Vis and fluorimetric spectroscopy. To explore and confirm the possibility of synthesized derivatives for their application as metal or pH sensors, UV/Vis and fluorimetric titrations of aqueous compounds solutions with aqueous solutions of metal chloride salts or different buffers were performed.[2] Additionally, the antioxidant properties of chosen compounds were determined by DPPH and FRAP methods.[3]

antioxidative activity ; benzamides ; chemosensors ; pH sensors

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