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Novel DNA/RNA-targeting amino acid beacon for the versatile incorporation at any position within the peptide backbone (CROSBI ID 238878)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Šmidlehner, Tamara ; Piantanida, Ivo Novel DNA/RNA-targeting amino acid beacon for the versatile incorporation at any position within the peptide backbone // Amino acids (Wien), 49 (2017), 8; 1381-1388. doi: 10.1007/s00726-017-2438-x

Podaci o odgovornosti

Šmidlehner, Tamara ; Piantanida, Ivo

engleski

Novel DNA/RNA-targeting amino acid beacon for the versatile incorporation at any position within the peptide backbone

One-pot tandem synthesis was for the first time applied to attach fluorophore to the amino acid side chain, yielding amino acid ready for peptide coupling at the N-terminus, and also upon activation at the C-terminus. Two new compounds differing only in fluorophore-linker length showed exceptional fluorimetric and CD recognition between DS-RNA and DS-DNA, thus being promising beacons for versatile peptide incorporation.

fluorescent amino acid ; one-pot synthesis ; DNA/RNA recognition ; fluorescence ; CD

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Podaci o izdanju

49 (8)

2017.

1381-1388

objavljeno

0939-4451

10.1007/s00726-017-2438-x

Povezanost rada

Kemija

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