Synthesis and characterization of homo- and heteroannularly substituted ferrocenoyl-cytosine derivatives (CROSBI ID 647967)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | domaća recenzija
Podaci o odgovornosti
Lapić, Jasmina ; Toma, Mateja ; Novaković, Anja ; Filipović, Alma ; Šakić, Davor ; Vrček, Valerije ; Djaković, Senka
engleski
Synthesis and characterization of homo- and heteroannularly substituted ferrocenoyl-cytosine derivatives
Pyrimidines and purines substituted by ferrocenyl moiety present interesting organometallic conjugates as their structures incorporate both biologically and electrochemically active components. The first syntheses of ferrocenyl-nucleobases were reported by Chen in 1980 [1, 2]. In our previous study were prepared ferrocenoylated N1-pyrimidine nucleobases (uracil, thymine and 5-fluorouracil). The synthetic procedure to obtain exclusively the N1-regioisomer does not require any protection of the N3-position in the nucleobase. The nucleophilic addition of pyrimidine bases to the carbonyl group of FcCOCl proceeds by a concerted SN2-like mechanism with the absence of the generally assumed tetrahedral intermediate. [3] This report will refer to the preparation procedure of homo- and heteroannularly substituted ferrocenoyl-cytosine derivatives. Regioselectivity of these reactions have been analyzed in details by NMR spectroscopy and quantum chemical calculations.
organometallic chemistry, electrochemistry, bioactive compounds, synthesis, reaction mechanism, DFT
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
Podaci o prilogu
139-139.
2017.
objavljeno
Podaci o matičnoj publikaciji
25. HRVATSKI SKUP KEMIČARA I KEMIJSKIH INŽENJERA s međunarodnim sudjelovanjem
Ana Šantić, Marijana Đaković
Zagreb: Hrvatsko kemijsko društvo
Podaci o skupu
25. hrvatski skup kemičara i kemijskih inženjera s međunarodnim sudjelovanjem
poster
19.04.2017-22.04.2017
Poreč, Hrvatska