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Synthesis and characterization of homo- and heteroannularly substituted ferrocenoyl-cytosine derivatives (CROSBI ID 647967)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | domaća recenzija

Lapić, Jasmina ; Toma, Mateja ; Novaković, Anja ; Filipović, Alma ; Šakić, Davor ; Vrček, Valerije ; Djaković, Senka Synthesis and characterization of homo- and heteroannularly substituted ferrocenoyl-cytosine derivatives // 25. HRVATSKI SKUP KEMIČARA I KEMIJSKIH INŽENJERA s međunarodnim sudjelovanjem / Ana Šantić, Marijana Đaković (ur.). Zagreb: Hrvatsko kemijsko društvo, 2017. str. 139-139

Podaci o odgovornosti

Lapić, Jasmina ; Toma, Mateja ; Novaković, Anja ; Filipović, Alma ; Šakić, Davor ; Vrček, Valerije ; Djaković, Senka

engleski

Synthesis and characterization of homo- and heteroannularly substituted ferrocenoyl-cytosine derivatives

Pyrimidines and purines substituted by ferrocenyl moiety present interesting organometallic conjugates as their structures incorporate both biologically and electrochemically active components. The first syntheses of ferrocenyl-nucleobases were reported by Chen in 1980 [1, 2]. In our previous study were prepared ferrocenoylated N1-pyrimidine nucleobases (uracil, thymine and 5-fluorouracil). The synthetic procedure to obtain exclusively the N1-regioisomer does not require any protection of the N3-position in the nucleobase. The nucleophilic addition of pyrimidine bases to the carbonyl group of FcCOCl proceeds by a concerted SN2-like mechanism with the absence of the generally assumed tetrahedral intermediate. [3] This report will refer to the preparation procedure of homo- and heteroannularly substituted ferrocenoyl-cytosine derivatives. Regioselectivity of these reactions have been analyzed in details by NMR spectroscopy and quantum chemical calculations.

organometallic chemistry, electrochemistry, bioactive compounds, synthesis, reaction mechanism, DFT

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Podaci o prilogu

139-139.

2017.

objavljeno

Podaci o matičnoj publikaciji

25. HRVATSKI SKUP KEMIČARA I KEMIJSKIH INŽENJERA s međunarodnim sudjelovanjem

Ana Šantić, Marijana Đaković

Zagreb: Hrvatsko kemijsko društvo

Podaci o skupu

25. hrvatski skup kemičara i kemijskih inženjera s međunarodnim sudjelovanjem

poster

19.04.2017-22.04.2017

Poreč, Hrvatska

Povezanost rada

Kemija, Farmacija

Poveznice