engleski

Age changes of lipid peroxidation in liver and thymus of CBA and AKR mice

Oxidative damage occuring in the process of aging or degenerative diseases seems to be at least partly a consequence of the imbalance between formation and removal of free radicals. Both increases and decreases of lipid peroxidation have been found as specific changes in developing or aging processes, in various species organs, tissues and sex.The aim of this study was to determine the age-and sex-associated differences in oxidant status in the liver and thymus from CBA and AKR mice. Since AKR mice spontaneously develops leukemia about 4-6 months after birth our attention was also focused to oxidant status of AKR mice related to ontogeny of thymic lymphoma and age in both sexes.The results showed that thiobarbituric acid reactive substances (TBARS) increased significantly with age in the liver of both sexes in CBA mice. On the contrary, thymus TBARS concentration was significantly increased only in males at 6 months of age, and it persisted to 12 months. TBARs concentration in female thymuses was unchanged during aging in both strains. A different pattern of TBARs concnetration was seen in the liver (12-month-old) and thymus (6-and 12-month-old) of AKR mice with developed thymomas. In summary, oxidant status in CBA mice is age-related in the liver in both sexes, while in thymus is age-related in male mice only. However, it seems that oxidant status in AKR mice are more closely linked with appearance of thymic lymphoma than being tissue-or sex-associated.

lipid peroxidation; age; liver; thymus; mice

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