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Pregled bibliografske jedinice broj: 878472

Časopis

Autori: Herrera-Molina, Rodrigo; Mlinac Jerković, Kristina; Ilić, Katarina; Stöber, Franziska; Vemula, Sampath Kumar; Sandoval, Mauricio; Jovanov Milošević, Nataša; Šimić, Goran; Smalla, Karl-Heinz; Goldschmidt, Jürgen; Kalanj Bognar, Svjetlana; Montag, Dirk
Naslov: Neuroplastin deletion in glutamatergic neurons impairs selective brain functions and calcium regulation: implication for cognitive deterioration
Izvornik: Scientific Reports (2045-2322) 7 (2017), 1; 7273-1-7273-13
Vrsta rada: članak
Ključne riječi: neuroplastin ; PMCA ; cognition mechanisms ; glutamatergic neurons, calcium homeostasis ; learning impairment ; memory deficits ; synaptopathy
Sažetak:
The cell adhesion molecule neuroplastin (Np) is a novel candidate to influence human intelligence. Np-deficient mice display complex cognitive deficits and reduced levels of Plasma Membrane Ca2+ ATPases (PMCAs), an essential regulator of the intracellular Ca2+ concentration ([iCa2+]) and neuronal activity. We show abundant expression and conserved cellular and molecular features of Np in glutamatergic neurons in human hippocampal- cortical pathways as characterized for the rodent brain. In Nptnlox/loxEmx1Cre mice, glutamatergic neuron-selective Np ablation resulted in behavioral deficits indicating hippocampal, striatal, and sensorimotor dysfunction paralleled by highly altered activities in hippocampal CA1 area, sensorimotor cortex layers I-III/IV, and the striatal sensorimotor domain detected by single-photon emission computed tomography. Altered hippocampal and cortical activities correlated with reduction of distinct PMCA paralogs in Nptnlox/loxEmx1Cre mice and increased [iCa2+] in cultured mutant neurons. Human and rodent Np enhanced the post- transcriptional expression of and co-localized with PMCA paralogs in the plasma membrane of transfected cells. Our results indicate Np as essential for PMCA expression in glutamatergic neurons allowing proper [iCa2+] regulation and normal circuit activity. Neuron-type-specific Np ablation empowers the investigation of circuit-coded learning and memory and identification of causal mechanisms leading to cognitive deterioration.
Projekt / tema: HRZZ-IP-09-2014-9730
Izvorni jezik: ENG
Current Contents: DA
Citation Index: DA
Ostale indexne publikacije: MEDLINE
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
Tiskani medij: da
URL Internet adrese: https://www.nature.com/articles/s41598-017-07839-9
Broj citata:
Altmetric:
DOI: 10.1038/s41598-017-07839-9
Časopis izlazi u samo elektroničkom izdanju: DA
Google Scholar: Neuroplastin deletion in glutamatergic neurons impairs selective brain functions and calcium regulation: implication for cognitive deterioration
Upisao u CROSBI: Kristina Mlinac (kmlinac@mef.hr), 31. Svi. 2017. u 12:57 sati



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