engleski

Acute salt loading affects post-occlusive reactive hyperemia in skin microcirculation independently of blood pressure changes in young healthy men

Introduction: We have reported that acute high- salt (HS) loading significantly impairs microvascular and macrovascular reactivity independently of blood pressure (BP) changes in young healthy women. This study aimed to assess whether 7-days HS intake affects microvascular reactivity in skin microcirculation in young healthy men and to evaluate whether these changes are independent of BP as in young healthy women. Methods: 13 young healthy men participated in this study (age range 19-24). Subjects took 7 day low-salt diet (<3.2 g salt/day) and 7-days HS diet (~14 g salt/day). Skin microvascular post- occlusive reactive hyperemia (PORH) was measured using laser Doppler flowmetry before and after diet protocols. Body mass index (BMI), waist-to- hip ratio (WHR), BP and heart rate (HR) were measured, and venous blood and 24h urine samples were analyzed for sodium, potassium, urea and creatinine levels before and after diet protocols. Results: There was no significant difference in BMI and WHR before and after HS diet. Changes in 24h urinary sodium confirmed subjects conformed to the diet protocol. There was no change in BP and HR before and after HS diet. HS diet provoked significant impairment of PORH in forearm skin microcirculation (PORH before 135±29% vs. after HS diet 112±27%, P=0.038). Conclusion: The results of this study demonstrated that 7-days HS loading induced significant impairment of skin microvascular reactivity in young healthy men, without changes in BP, and confirmed our previous results obtained in young healthy women population. Furthermore, it provides evidence that HS intake - related microcirculatory function impairment is sex- independent.

high salt diet, microvascular reactivity, laser Doppler flowmetry, blood pressure

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