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Synthesis and antioxidative potency of novel amidino substituted benzimidazole and benzothiazole derivatives (CROSBI ID 240132)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Racané, Livio ; Cindrić, Maja ; Perin, Nataša ; Roškarić, Petra ; Starčević, Kristina ; Mašek, Tomislav ; Maurić, Maja ; Dogan, Jasna ; Karminski-Zamola, Grace Synthesis and antioxidative potency of novel amidino substituted benzimidazole and benzothiazole derivatives // Croatica chemica acta, 90 (2017), 2; 187-195. doi: 10.5562/cca3146

Podaci o odgovornosti

Racané, Livio ; Cindrić, Maja ; Perin, Nataša ; Roškarić, Petra ; Starčević, Kristina ; Mašek, Tomislav ; Maurić, Maja ; Dogan, Jasna ; Karminski-Zamola, Grace

engleski

Synthesis and antioxidative potency of novel amidino substituted benzimidazole and benzothiazole derivatives

Herein we present the synthesis of versatile amidino substituted benzothiazole 3-10 and benzimidazole 12-19 derivatives substituted with the variable number of hydroxy and methoxy groups. Furthermore, the synthesized compounds were explored for their antioxidative activity in vitro by using three biological assays, namely DPPH, ABTS and FRAP. The obtained results indicated that the variable number of hydroxy groups together with the type of the amidino substituent strongly influenced the antioxidative activity and reducing power of tested compounds. The most promising antioxidative activity showed trihydroxy substituted compounds 6, 10, 15 and 19. In general, it was noticed that unsubstituted amidino group induced the more pronounced activity in comparison to derivatives bearing 2- imidazolinyl group.

amidines ; benzimidazoles ; benzothiazoles ; antioxidative activity in vitro

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Podaci o izdanju

90 (2)

2017.

187-195

objavljeno

0011-1643

1334-417X

10.5562/cca3146

Povezanost rada

Interdisciplinarne prirodne znanosti, Kemija, Veterinarska medicina

Poveznice
Indeksiranost