engleski

Primary uterine and ovarian cancers in patients diagnosed with breast cancer: a case report

Previous large studies suggest that, among breast cancer survivors, the risk of developing second primary nonmammary neoplasms is higher than in the general population. Our patient, a 47-year-old female patient with a positive familial history of breast cancer, was diagnosed with breast cancer nine years ago. After a mastectomy she was treated with irradiation and chemotherapy. Subsequently, a tamoxifen citrat therapy was introduced because of the positive immunohistochemical test results of estrogens and progestogenes tumour receptors. Almost a decade after she was admitted to the gynecology ward because of vaginal bleeding. A hysterectomy with a bilateral oophorectomy was performed. Pathohistological analyses revealed an endometrioid adenocarcinoma of the endometrium synchronous with clarcellular carcinoma of the one ovary (FIGO III). No gene mutations of BRCA1 and BRCA2 were detected. Although BRCA1 and BRCA2 founder mutations predispose a specific subset of patients to carcinoma of the breast and ovary, the majority of these cancers are sporadic. Furthermore, it can be argued that radiotherapy, adjuvant chemotherapy and tamoxifen are associated with the development of second primary nonmammary neoplasms, especially in the breast cancer population in which these modalities are a part of the treatment. Even though the risk of individual second primary cancers cannot be reliably assessed due to today’s limited knowledge, preventive strategies, continued monitoring and early detection of second neoplasms may be wise precautions for this patient population.

Primary uterine cancer ; ovarian cancer ; breast cancer

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