engleski

Biochemical markers of bone turnover in Croatian Warmblood horses undergoing medium level show jumping exercise

Bone turnover is a lifelong process during which the bone tissue undergoes processes that are physiologically in balance, formation and resorption.The aim of this study was to establish a profile of serum concentrations of biomarkers of bone turnover in Croatian Warmblood horses. Blood samples from 28 healthy horses used for medium level show jumping exercise were used in this study. Horses were trained for an average of six days per week with standard exercise of walking, trotting, cantering and jumping. Blood sampling was performed at the same time of the day with an aim to reduce diurnal variations. The samples were processed using commercially available human assays, validated for use in horses, for evaluation of bone alkaline phosphatase (BALP), osteocalcin (OC) and carboxy-terminal cross- linked telopeptide of type I collagen (CTX). The effects of age and gender on biomarker concentration were analysed. The concentrations of BALP and CTX peaked in youngest horses and all biomarkers showed a progressive decline with age. Gender difference in biomarker concentration was noted only for CTX with male horses having higher values. There was no statistically significant correlation between studied biomarkers, although their similar trends suggested that serum levels of bone resorption markers follow the same evolution as bone formation markers. The results of this study indicate that during the first years of show jumping training there is still pronounced bone turnover

bone alkaline phosphatase ; bone turnover ; carboxy-terminal cross-linked telopeptide of type I collagen ; equine ; osteocalcin ; Warmblood horse

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