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Antitumoral and antiviral activities of novel 1, 2, 3-triazolyl appended L-asorbic acid derivates

L-Ascorbic acid is known as a ubiquitous carbohydrate of vital importance in living beings. Some pyrimidine and purine derivatives of 4, 5-didehydro-5, 6-dideoxy- and 6-deoxy-L- ascorbic acid exhibited selective and efficient cytostatic activities and displayed antiviral activities.[1] The 1, 2, 3-triazole moiety is extensively used in medicinal chemistry as a pharmacophore to modify known bioactive molecules and to potentiate their biological activities.[2, 3] Although click reactions are traditionally conducted in batch process, the progress toward increased sustainability that requires novel approaches with reduced environmental impact opened up in recent years continuous-flow as a novel alternative to conventional batch-based synthesis.[4] Realizing the benefits of flow chemistry as green and sustainable process and in continuation of our study towards the synthesis of 1, 2, 3-triazole-containing heterocycle pharmacophores, our aim was to improve the practical applicability of Cu(I)-catalyzed azide– alkyne 1, 3-dipolar cycloaddition (CuAAC) to provide diverse C-6-substituted 1, 2, 3-triazolyl 4, 5-unsaturated L-ascorbic acid derivatives using innovative enabling ultrasound and continuous flow hybrid system. Some compounds of presented series exhibit selective antiproliferative activities which will be demonstrated along with their antiviral potency

L-ascorbic acid ; 1, 2, 3-triazole ; antitumoral ; antiviral ; antioxidant evaluation

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