engleski

Synthesis, antitumor and antioxidative activity of nitro and amino substituted benzimidazole and benzothiazole 2-carboxamides

Heterocyclic compounds containing benzimidazole and benzothiazole have been found very interesting to medicinal and organic chemists and are extensively studied due to their well known and wide biological activities. Over the past several years we have become interested in antitumor activity of different derivatives of benzimidazole and benzothiazole carboxamides, and recently in their antioxidative activity [1, 2]. Oxidative stress, as a result of excessive production and accumulation of free radicals, is one of the leading causes of many degenerative diseases such as Alzheimer's and Parkinson's disease, inflammatory processes and DNA damage leading to carcinogenesis. In this report we present synthesis, antitumor and antioxidative activity of novel nitro and amino substituted benzimidazole and benzothiazole carboxamides. For the synthesis of novel compounds we have used methods of classical linear organic synthesis starting from aromatic acyl halogenides which gave in the reaction with substituted 2-s or 2-aminobenzothiazoles corresponding carboxamides. Antiproliferative activity in vitro of selected compounds was tested on several human tumor cell lines and the antioxidant properties were determined by DPPH and FRAP methods [3].

benzimidazole and benzothiazole carboxamides ; antitumor activity ; antioxidative activity

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