Humani serumski albumin – najvažniji transportni protein u krvi (CROSBI ID 240882)
Prilog u časopisu | stručni rad | domaća recenzija
Podaci o odgovornosti
Rimac, Hrvoje ; Bojić, Mirza
hrvatski
Humani serumski albumin – najvažniji transportni protein u krvi
Human serum albumin (HSA) is the most abundant protein in human serum. It has numerous functions, one of which is transport of small hydrophobic molecules, such as metabolites, hormones, and nutrients, as well as drugs and toxins. This promiscuous, nonspecific affinity can lead to competition and displacement of different ligand in binding to HSA and cause increase in toxicity of displaced ligands. In this paper, the most important HSA binding sites are described and the risk of displacement interactions between different ligands is discused. While such interactions are more common between physiological (e.g. fatty acids, bilirubin, heme etc) and patophysiological ligands (e.g. indoxyl sulfate, indol-3-acetate, hypuric acid, and CMPF) and drugs, displacement interactions between drugs are also known. In certain cases these interactions can directly influence drug’s free, active concentration in blood.
HSA, lijekovi
nije evidentirano
engleski
Human serum albumin – the most important transport protein in the blood
nije evidentirano
HSA, drugs
nije evidentirano