ALTERED SLEEP STRUCTURE AND BREATHING IN CHILDREN WITH DOWN SYNDROME – A NEED FOR ROUTINE POLYSOMNOGRAPHIC STUDIES (CROSBI ID 650774)
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Podaci o odgovornosti
Gjergja-Juraski , Romana ; Turkalj , Mirjana ; Plavec , Davor ; Nogalo , Boro ; Nenadic- Baranasic , Natasa ; Stipoljev , Feodora ; Marusic , Ivana ; Ordulj-Anicic , Darija ; Miloš , Marija ; Anzic , Ante.
engleski
ALTERED SLEEP STRUCTURE AND BREATHING IN CHILDREN WITH DOWN SYNDROME – A NEED FOR ROUTINE POLYSOMNOGRAPHIC STUDIES
Down syndrome (DS) is the most common genetic cause of intellectual impairment. Children with intellectual disabilities have frequently more sleep issues than general population of children. Obstructive sleep apnea (OSA) has prevalence in general population 1-4%, but in children with DS it increases up to 63%. Despite these facts, there are limited studies analyzing the sleep issues in children with DS and there is still no well recognizable sleep phenotype in DS, or listed as an important clinical feature of DS. There have been some animal model studies which investigated the genotype of the sleep in DS and so far some genes have been listed as gene candidates for the sleep phenotype not only in DS, especially of obstructive sleep apnea syndrome. METHODS: Our study examines the sleep issues in a cohort of Croatian children with DS, using overnight polysomnography. RESULTS: Our data showed that children with DS had short sleep latency, but long REM latency, increased total wake time, low number, but long duration of arousals, higher percentage of N1 and lower percentage of REM and N3 sleep, compared to their age. All these issues lead to the sleep fragmentation in our group of children with DS. CONCLUSION: Promoting the importance of having the routine sleep overnight study in children with DS and addressing the awareness of sleep issues to the health care providers who care for DS and to the parents of children with DS, we can prevent majority of respiratory complications in children with DS.
Down syndrome, overnight polysomnography, children
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Podaci o prilogu
2017.
objavljeno
Podaci o matičnoj publikaciji
Podaci o skupu
10th ISABS Conference
poster
19.06.2017-24.06.2017
Dubrovnik, Hrvatska