Active modulation in neat carbon dioxide packed column comprehensive two-dimensional supercritical fluid chromatography (CROSBI ID 241985)
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Podaci o odgovornosti
Petković, Orjen ; Guibal, Pierre ; Sassiat, Patrick ; Vial, Jérôme ; Thiébaut, Didier
engleski
Active modulation in neat carbon dioxide packed column comprehensive two-dimensional supercritical fluid chromatography
After demonstrating in a first paper the feasibility of SFCxSFC without decompression of the mobile phase, a modified interface has been developed in order to perform active modulation between the two SFC dimensions. In this paper, it is shown that the new interface enabled independent control of modulation parameters in SFCxSFC and performed a band compression effect of solutes between the two SFC dimensions. The effectiveness of this new modulation process was studied using a Design of Experiments. The SFCxSFC prototype was applied to the analysis of a real oil sample to demonstrate the benefits of the active modulator ; in comparison to our previous results obtained without active modulation, better separation was obtained with the new interface owing to the peak compression occurring in the modulator.
chromatograpy ; 2D chromatograpy ; supercritical fluid chromatography
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Podaci o izdanju
1536
2017.
176-184
objavljeno
0021-9673
1873-3778
10.1016/j.chroma.2017.08.063