12 X-chromosome STR markers in the population of south Croatia (CROSBI ID 651863)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa
Podaci o odgovornosti
Korolija, Marina ; Ozretić, Petar ; Crnjac, Josip ; Merkaš, Siniša ; Račić, Ivana ; Rožić, Sara ; Sukser, Viktorija ; Barbarić, Lucija ; Popović, Maja ; Mršić, Gordan
engleski
12 X-chromosome STR markers in the population of south Croatia
Short tandem repeat (STR) markers have been used in forensic identification and kinship testing for decades. Routinely used autosomal STRs provide sufficient information for personal identification. However, forensic casework samples are usually of low quantity, contaminated and degraded, yielding partial and/or mixed profiles. X-STR profiling can in that sense assist identification in forensic investigations as an additional source of information. Moreover, because of its unique pattern of inheritance, X-STR typing has been proved useful in kinship testing. Therefore we assessed applicability of Investigator® Argus X-12 Kit for routine forensic work involving Croatian population. 12 X-STR loci belonging to four linkage groups were co-amplified and analyzed by capillary electrophoresis in 298 female and 301 male DNA samples of unrelated donors. Computations based on allele and haplotype frequencies were performed. Forensic parameters, linkage disequilibrium and genetic distance from ten non-Croatian populations have been determined. In female samples, Hardy- Weinberg equilibrium was confirmed for all X- STR markers. DXS10135 was the most, while DXS8378 was the least informative marker. In both male and female samples, combined power of discrimination exceeded 0.999999999. Linkage group 1 was the most informative. Significant genetic distance from south Croatia population was confirmed for Greenlandic, and three non- European populations. In conclusion, Investigator® Argus X-12 Kit can be used in forensic casework for both identification and familial testing in the population of south Croatia.
X-STR ; Investigator® Argus X-12 ; Population study ; South Croatia ; Forensics
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
Podaci o prilogu
132-132.
2017.
objavljeno
Podaci o matičnoj publikaciji
10th ISABS Conference on Forensic and Anthropologic Genetics and Mayo Clinic Lectures in Individualized Medicine
Primorac, Dragan ; Schanfield, Moses ; Vuk-Pavlović, Stanimir ; Kayser, Manfred ; Ordog, Tamas
Zagreb: International Society for Applied Biological Sciences (ISABS)
978-953-57695-2-1
Podaci o skupu
10th ISABS Conference on Forensic and Anthropologic Genetics and Mayo Clinic Lectures in Individualized Medicine
poster
19.06.2017-24.06.2017
Dubrovnik, Hrvatska