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Progesterone Induced Blocking Factor (PIBF) Mediates Progesterone Induced Suppression of Decidual Lymphocyte Cytotoxicity (CROSBI ID 95872)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Laškarin, Gordana ; Sotosek Tokmadžić, Vlatka ; Štrbo, Nataša ; Bogovic, Tatjana ; Szekeres-Bartho, Julia ; Randić, Ljiljana ; Podack, Eckhard R. ; Rukavina, Daniel Progesterone Induced Blocking Factor (PIBF) Mediates Progesterone Induced Suppression of Decidual Lymphocyte Cytotoxicity // American journal of reproductive immunology, 48 (2002), 4; 201-210. doi: 10.1034/j.1600-0897.2002.01133.x

Podaci o odgovornosti

Laškarin, Gordana ; Sotosek Tokmadžić, Vlatka ; Štrbo, Nataša ; Bogovic, Tatjana ; Szekeres-Bartho, Julia ; Randić, Ljiljana ; Podack, Eckhard R. ; Rukavina, Daniel

engleski

Progesterone Induced Blocking Factor (PIBF) Mediates Progesterone Induced Suppression of Decidual Lymphocyte Cytotoxicity

PROBLEM: Progesterone induced blocking factor (PIBF) is a mediator of progesterone that blocks peripheral blood lytic natural killer (NK) activity. Progesterone or PIBF stimulated decidual macrophages block up-regulation of perforin expression in decidual lymphocytes (DL). Therefore, we investigated whether progesterone regulates cytotoxicity of DL. METHOD OD STUDY: Decidual mononuclear cells were cultured with progesterone. PIBF, progesterone and anti-PIBF antibody or in the medium only. Cytolytic activity of non-adherent DL was measured by PKH-26 (red) 2 hr cytolytic assay and flow cytometry. Perforin positive DL were detected by immunofluorescency and PIBF-positive cells by immunohistology. RESULTS: Progesterone and PIBF, in a dose-dependent manner decreased cytotoxicity of DL against K-562 targets, and perforin egzocytosys was blocked. Anti-PIBF antibodies reversed the progesterone mediated reduction in cytolytic activity of DL. PIBF positive cells were found in first trimester pregnancy decidua. CONCLUSION: The results indicate possible role for PIBF, as a mediator of progesterone in regulation of DL cytolytic activity at the maternal-foetal (M-F) interface.

Decidual lymphocytes ; NK cytotoxicity ; Perforin ; PIBF ; Pregnancy ; Progesterone

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Podaci o izdanju

48 (4)

2002.

201-210

objavljeno

1600-0897

10.1034/j.1600-0897.2002.01133.x

Povezanost rada

Temeljne medicinske znanosti

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