Nalazite se na CroRIS probnoj okolini. Ovdje evidentirani podaci neće biti pohranjeni u Informacijskom sustavu znanosti RH. Ako je ovo greška, CroRIS produkcijskoj okolini moguće je pristupi putem poveznice www.croris.hr
izvor podataka: crosbi

Design of Small Molecular Probes for Proteins and DNA / RNA (CROSBI ID 652986)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa

Piantanida, Ivo Design of Small Molecular Probes for Proteins and DNA / RNA // Book of Abstracts of the 10th Joint Meeting on Medicinal Chemistry / Basarić, Nikola ; Namjesnik, Danijel ; Perković, Ivana et al. (ur.). Zagreb: Hrvatsko kemijsko društvo, 2017. str. 41-41

Podaci o odgovornosti

Piantanida, Ivo

engleski

Design of Small Molecular Probes for Proteins and DNA / RNA

Small molecules targeting DNA, RNA and/or proteins have attracted significant scientific interest not only because of their biomedicinal applications, but also due to widespread use of spectrophotometric markers in the related scientific research. For instance, fluorescent techniques significantly developed during the last three decades and now represent about 70% of the detection enabling technologies used in molecular biology and medicine. However, design of small molecule (Mw<600) for recognition of ds-DNA/RNA sequence or particular protein is very challenging due limited number of modifications in such restricted molecule size. Quite often, small modifications lead to change of target preference, for instance from DNA-targeting to protein-targeting molecule One of our research lines is focused on the generally under-investigated approach: exploitation of intrinsic property of some dyes for aggregation, whereby monomeric and aggregated dye differ strongly not only in target recognition but also in spectroscopic properties1. Thus, one dye molecule could bind with similar affinity to several targets (DNA, RNA, protein) giving different spectroscopic responses for each target: to some polynucleotide sequence dye would bind as monomer, for other sequence as dimer, and protein binding site would induce different spectroscopic response (Scheme 1). The ongoing research endeavours to establish for the low molecular weight dyes the structure-activity guidelines for fine tuning of DNA - RNA - protein preferences combined with recognition by set of sensitive and bio-applicable spectrometric methods.

DNA recognition ; protein recognition ; fluorescence ; CD ; aggregation

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o prilogu

41-41.

2017.

objavljeno

Podaci o matičnoj publikaciji

Book of Abstracts of the 10th Joint Meeting on Medicinal Chemistry

Basarić, Nikola ; Namjesnik, Danijel ; Perković, Ivana ; Stepanić, Višnja

Zagreb: Hrvatsko kemijsko društvo

978-953-55232-8-4

Podaci o skupu

10th Joint Meeting on Medicinal Chemistry

ostalo

25.06.2017-28.06.2017

Srebreno, Hrvatska; Dubrovnik, Hrvatska

Povezanost rada

Kemija