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Pregnancy induced changes of cytotoxic activity of conventional and extrathymic lymphatic cells in mice. (CROSBI ID 485134)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija

Šimin, Marija ; Radić, Davor ; Mrakovčić-Šutić, Ines ; Ćuk, Mira ; Radošević-Stašić, Biserka ; Rukavina, Daniel Pregnancy induced changes of cytotoxic activity of conventional and extrathymic lymphatic cells in mice. // American Journal of Reproductive Immunology / Gleicher, Norbert (ur.). Chicago (IL): The American Society for Reproductive Immunology, 2001. str. 101-101-x

Podaci o odgovornosti

Šimin, Marija ; Radić, Davor ; Mrakovčić-Šutić, Ines ; Ćuk, Mira ; Radošević-Stašić, Biserka ; Rukavina, Daniel

engleski

Pregnancy induced changes of cytotoxic activity of conventional and extrathymic lymphatic cells in mice.

Problem: The immune compromise in decidua allows a semiallogeneic fetus to survive without impairing the ability of the maternal immune system to fight infections. Success of pregnancy depends on fetal trophoblast cells, which form the interface with the mother and express monomorphic, non classical HLA or MHC class I antigens, like CD1d or HLA-G, which protects cells against natural killer (NK) cell lysis and against allo-cytotoxic T lymphocyte responses. Peripheral maternal immunity, however, remains, generally preserved, although during pregnancy and early puerperium an immune balance in favor of suppression was noted, as well an immunomodulation of cytokine responses towards the Th2 paradigm. A specific function in these events seems to have also extrathymically generated NK and NKT cells, which show synchronous expansion in the liver and in the pregnant uterus. Method of study: To elucidate the pregnancy-induced changes in the mother at the sites of extrathymic and conventional T cell generation, in this study we made phenotypic and functional characterization of maternal mononuclear lymphatic cells in the liver, thymus and spleen, using FACS analysis and testing their cytotoxicity against NK and NKT sensitive targets. Experiments were performed in both syngeneic and allogeneic combinations of mating. Results: The data showed that maternal liver in the late phase of syngeneic pregnancy contains more NK1.1.+ and CD4+ cells than have non-pregnant mice. In the spleen an increased proportion of CD3+ and CD4+ cells was also noticed. Preliminary data also showed that cytotoxicity of splenic cells, obtained from mice at the 16th day of syngeneic pregnancy against NK sensitive Yac-1 targets is markedly increased. Conclusion: The data point to the liver as a site of extrathymic T cell generation in both types of pregnancies, and emphasize that changes in the cytotoxic activities of maternal NK and NKT cells, found in the syngeneic pregnancy, might be linked not only with semiallogeneic nature of the fetus, but also with other physiological functions of innate and adaptive immunity.

syngeneic pregnancy; Liver

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Podaci o prilogu

101-101-x.

2001.

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objavljeno

Podaci o matičnoj publikaciji

American Journal of Reproductive Immunology

Gleicher, Norbert

Chicago (IL): The American Society for Reproductive Immunology

Podaci o skupu

VIII International Congress of Reproductive Immunology.

poster

02.07.2001-06.07.2001

Opatija, Hrvatska

Povezanost rada

Temeljne medicinske znanosti