Nalazite se na CroRIS probnoj okolini. Ovdje evidentirani podaci neće biti pohranjeni u Informacijskom sustavu znanosti RH. Ako je ovo greška, CroRIS produkcijskoj okolini moguće je pristupi putem poveznice www.croris.hr
izvor podataka: crosbi !

Total serum cholesterol increases risk for development and progression of nonproliferative retinopathy in patients with type 1 diabetes without therapeutic intervention: prospective, observational study (CROSBI ID 244225)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Bulum, Tomislav ; Tomić, Martina ; Duvnjak, Lea Total serum cholesterol increases risk for development and progression of nonproliferative retinopathy in patients with type 1 diabetes without therapeutic intervention: prospective, observational study // Archives of medical research, 48 (2017), 5; 467-471. doi: 10.1016/j.arcmed.2017.10.003

Podaci o odgovornosti

Bulum, Tomislav ; Tomić, Martina ; Duvnjak, Lea

engleski

Total serum cholesterol increases risk for development and progression of nonproliferative retinopathy in patients with type 1 diabetes without therapeutic intervention: prospective, observational study

Results from studies investigating relationship between serum lipids and risk of development and progression of diabetic retinopathy (DR) in patients with type 1 diabetes (T1DM) are not consistent. The objective of this study was to explore the relationship between serum lipids and risk of development and progression of nonproliferative diabetic retinopathy (NPDR) in T1DM with normal renal function. A total of 103 T1DM with normal renal function, and before any interventions with lipid-lowering therapy, ACE inhibitors or angiotensin II receptor blockers were included in this study and followed for 41 months. Photodocumented retinopathy status was made according to the EURODIAB protocol. Patients who developed NPDR or progressed to proliferative retinopathy were older (44 vs 33 years, p<0.001), had longer duration of diabetes (21.1 vs 13.3 years, p<0.001), and higher serum total cholesterol level (5.1 vs 4.5 mmol/L, p=0.02) compared to patients without retinopathy. In a backward stepwise Cox's multiple regression analysis serum total cholesterol was significantly associated with risk of development or progression of NPDR in our subjects (p=0.04), with odds ratios of 1.27 to 1.91. These data suggest that serum total cholesterol levels are associated with risk of development and progression of NPDR in T1DM and normal renal function. The study was conducted in patients with no therapeutic interventions.

retinopathy ; type 1 diabetes ; total cholesterol

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o izdanju

48 (5)

2017.

467-471

objavljeno

0188-4409

1873-5487

10.1016/j.arcmed.2017.10.003

Povezanost rada

Kliničke medicinske znanosti

Poveznice
Indeksiranost