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Cytolytic mechanisms at the maternal-fetal interface" (Lectures on "Recent advances in immunology"), Invited Lecture, European Meeting of Immunology and Reproduction, Rome, October 28-29, 1999. (CROSBI ID 485358)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija

Rukavina, Daniel Cytolytic mechanisms at the maternal-fetal interface" (Lectures on "Recent advances in immunology"), Invited Lecture, European Meeting of Immunology and Reproduction, Rome, October 28-29, 1999. // Final program and abstract book / Dondero, Franco ; Lenzi, Andrea (ur.). Rim: University of Rome, 1999. str. 80-80-x

Podaci o odgovornosti

Rukavina, Daniel

engleski

Cytolytic mechanisms at the maternal-fetal interface" (Lectures on "Recent advances in immunology"), Invited Lecture, European Meeting of Immunology and Reproduction, Rome, October 28-29, 1999.

Cytotoxic T lymphocytes (CTL) and Natural killer (NK) cells, mediators in acute cytolytic pathway, are present at the maternal-fetal interface. At the molecular level acute cytotoxicity is mediated by Perforin and Granzymes and Fas-Fas Ligand (FasL) pathways. In the absence of both cytotoxic pathways (double deficiency in mice, CDD) CTL and NK cells are unable to remove macrophages from decidua resulting in untrammeled T lymphocyte activation, autoimmune destruction and infertility. Female mice homozygous for FasL defect but heterozygous for Perforin locus reproduce normally, which supports hypothesis that Perforin in decidual lymphocytes contributes to the homeostasis of pregnant state including maintenace of Th2 phenotype, by eliminating antigen presenting cells that are biased towards Th1 production. Decidual NK (dNK) cells are predominant lymphocyte population at the maternal-fetal interface in humans and they are fully equipped with Perforin (bright). The level of Perforin expression at so high levels: 1) decidual macrophages and stromal cells, 2) hormones, and 3) cytokines. Critical role is ascribed to IL-15 at the interface. IL-15 maximally primes cytolitic armamentarium (upregulation of Perforin expression) for function (killing) during pregnancy, but simultaneously downregulates cytotoxicity, which prevents accidental activation under physiological circumstances. However, in pathological conditions (Th1 cytokines predominance) this pathway can be triggered.

Maternal-fetal interface; Fas-Fas Ligand; Decidual NK cells; IL-15

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Podaci o prilogu

80-80-x.

1999.

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objavljeno

Podaci o matičnoj publikaciji

Final program and abstract book

Dondero, Franco ; Lenzi, Andrea

Rim: University of Rome

Podaci o skupu

European Meeting of Immunology and Reproduction and joint Meeting 5th Congress of the Alps Adria Society of Immunology of Reproduction

pozvano predavanje

28.10.1999-29.10.1999

Rim, Italija

Povezanost rada

Temeljne medicinske znanosti