engleski

Osteopontin expressing macrophages predict survival in diffuse large B cell lymphoma

Objective: Osteopontin (OPN) is cell adhesion molecule and cytokine expressed by many tumour cells as well as tumour associated macrophages (TAMs). The aim of this pilot study was to analyse the prognostic significance of osteopontin expressed by TAMs in patients with diffuse large B-cell lymphoma (DLBCL). Method: The expression of osteopontin in TAMs was analyzed immunohistochemically on tissue microarrays of 81 DLBCLs. OPN expression was scored semiquantitatively as low, moderate or strong. The level of OPN expression in TAMs was correlated with clinicopathological data and overall patient’s survival. Results: Low OPN expression was found in 32 cases (40 %), moderate in 31 (38 %) and strong in 18 cases (22 %). High level of OPN expression in TAMs was associated with increased international prognostic index (p < 0.001) and high serum LDH level. There was a trend toward the association of low OPN level and complete response to therapy (p < 0.06). Also, higher level of OPN expression in TAMs was associated with poor overall survival (p < 0.04). Conclusion: OPN expressed by TAMs is potential prognostic factor in DLBCL patients.

Osteopontin ; tumour associated macrophages ; diffuse large B-cell lymphoma ; prognosis

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