engleski

Prognostic importance of NF-kappaB in breast cancer

Aim: Nuclear factor κB (NF-κB) is transcriptional factor involved in cancerogenesis and metastatic spread of tumors cells. The aim of this study was to evaluate expression of NF-κB in breast cancer and to correlate the immunohistocemical expression of this marker with clinicopathological parameters and patient outcome. Materials and metods: This retrospective study included 208 consecutive newly diagnosed ductal invasive breast cancer patients operated at Department of Surgery, Clinical Hospital Center Rijeka, Croatia between 2000 and 2004 with long term follow up over 10 years. Immunohistochemical staining for NF-kB was done on tissue microarray and expression in more than or equal to 10% nuclei of entire tumor area was considered positive. Results: NF-κB was positive in 62 or 31% of tumors. Activation of NF-kB showed inverse correlation with expression of estrogen receptor (p=0.005) and positive correlation with expression Ki-67 proliferation index (p=0, 015). Tumors were classified as Luminal A (ER and/or PR positive, Her-2 negative, Ki-67 <20%) in 53% cases. In our study 5-year overall survival was 71%±3%, while 10-year OS was 61% ±4%. Out of the 200 patients with complete follow up 72 (36%) died. We found better overall survival in NF-kB positive tumors in Luminal A subtype (p=0.021). Conclusion: Our results could be explained as consequence of possible tumor suppressing effect of NF-kB. We think that the practical relevance of NF-kB as prognostic indicator and potential target for specific therapies deserve further investigation.

Nf-kappaB, breast cancer

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