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izvor podataka: crosbi

Changes of Cytoloytic Cells and Perforin Expression in Patients with Posttraumatic Stress Disorder (CROSBI ID 96227)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Škarpa, Ivona ; Rubeša, Gordana ; Moro, Ljiljana ; Manestar, Darko ; Petrovečki, Mladen ; Rukavina, Daniel Changes of Cytoloytic Cells and Perforin Expression in Patients with Posttraumatic Stress Disorder // Croatian medical journal, 42 (2001), 5; 551-555-x

Podaci o odgovornosti

Škarpa, Ivona ; Rubeša, Gordana ; Moro, Ljiljana ; Manestar, Darko ; Petrovečki, Mladen ; Rukavina, Daniel

engleski

Changes of Cytoloytic Cells and Perforin Expression in Patients with Posttraumatic Stress Disorder

Aim is to define phenotipic characteristics of cytotoxic T lymphocytes (CTL) and natural killer cells (NK) in peripheral blood, frequency of somatic symptoms, and level of anxiety and depression in 25 patients clinically diagnosed with chronic post-traumatic stress disorder (PTSD). Patients were divided into two sub-groups according to the stressor: 18 PTSD patients with combat experience and 7 PTSD patients with combat experienca who were tortured as the prisoners of war (POW) in Bosnian-Serbian camps. The control group consisted of 15 healthy volunteers matched to the patients by sex and age. We tested all patients using the Beck Depression Inventory, Spilberg anxiety test, and somatic disturbance list, and analyzed their peripheral blood lymphocytes using flow cytometry with the double flourescence staining of cell surface antigens (CD3, CD4, CD8, CD16, and CD56) and intra cellular cytolytic molecule perforin (P) a mediator of cytolytic action at the molecular level. All PTSD patients showed a significant level of anxiety, depression and numerous somatic symptoms. The only difference between PTSD patients with and without POW experience was in the anxiety level (median, 71 ; range 61-79 ; vs median, 65 ; range 49-77). PTSD patients with POW experience had significantly higher level of CD16+ cells (median, 37% ; range 16-55%) than those without it (median, 12% ; range 5-37%). Double labelling for intracellular P antigen and cell surface antigens showed the highest of CD16+P+ (median 33% ; range 15-40% ; vs median, 10% ; range 3-29%) and CD56+P+ (median, 21% ; range 11-40% vs median, 8% ; range 1-30%) cells in PTSD-POW patients. In conclusion: chronic PTSD patients who survived concentration camps show the most numerous alterations in PBL phenotype, the highest number of perforine-containing cells, and a significantly higher level of anxiety.

Antigens CD56; Natural killer cells; Membrane proteins; Post-traumatic stress disorder; cytotoxic T-lymphocytes; veterans; war

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Podaci o izdanju

42 (5)

2001.

551-555-x

objavljeno

0353-9504

Povezanost rada

Kliničke medicinske znanosti

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